Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 29, Issue 13, Pages 1643-1655Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2018.1481005
Keywords
Hyaluronic acid; carboxymethyl cellulose; disulfide bond; hydrogel; injectable; drug release
Funding
- Scientific Research Foundation of Southwest University of Science and Technology of China [17zx7121]
- Longshan academic talent research supporting program of Southwest University of Science and Technology of China [17LZXT02]
- National Engineering Technology Center for Insulation Materials, Southwest University of Science and Technology of China [16kfjc02]
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A series of injectable in situ cross-linking hyaluronic acid/carboxymethyl cellulose based hydrogels (HA/CMC) was prepared via disulfide bonds by the oxidation of dissolved oxygen. The results showed that HA/CMC hydrogels exhibited tunable gelling time, appropriate rheology properties, high swelling ratio, good stability, and sustained drug release ability. The gelling time of HA/CMC hydrogels ranged from 1.4 to 7.0 min, and the values of the storage modulus, complex shear modulus, dynamic viscosity, and yield stress of HA3/CMC3 hydrogel were about 5869 Pa, 5870 Pa, 587 Pa.s, and 1969 Pa, respectively. The degradation percentage of HA1/CMC1, HA2/CMC2, and HA3/CMC3 hydrogels were about 60, 49, and 41% after incubating 42 days, and the in vitro cumulative release percentage of BSA from HA1/CMC1, HA2/CMC2, and HA3/CMC3 drug-loaded hydrogels were about 99, 91, and 82% after 30 days. The series of injectable in situ cross-linking HA/CMC hydrogels exhibited good comprehensive performance, signifying that these hydrogels could be potentially used in the fields of short-and medium-term controlled drug release, cell encapsulation, regenerative medicine, and tissue engineering. [GRAPHICS] .
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