Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 29, Issue 13, Pages 1595-1611Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2018.1477316
Keywords
Bioinert implant; peptide; silk fibroin; porous; PEEK; osteogenesis
Funding
- Sichuan Science and Technology Program [2017FZ0046, 2018JZ0026]
- China Postdoctoral Science foundation [2017M610600]
- Fundamental Research Funds for the Central Universities (Full-time Postdoctoral Research Fund of Sichuan University) [2017SCU12016]
- Shanghai Municipal Science and Technology Commission [18410711200]
- Hong Kong Scholars Program
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In this study, we develop an osteopromotive polyetheretherketone (PEEK) implant decorated with silk fibroin and bone forming peptide, in which the surface of bioinert PEEK implant is firstly sulfonated to form a three-dimensional, porous topography and then is functionalized with silk fibroin via spin-coating process and peptide decoration. The bio-test results show that cells on the functional bioinert implants exhibit better cell adhesion, proliferation and spreading, when compared with the uncoated ones. Moreover, the peptide-decorated silk fibroin coatings have ability to hasten the osteogenic differentiation and maturation of osteoblast-like cells. Our findings show the potential of the functional PEEK implants with superior bioactivity and osteoinductive property in orthopedics and dentistry. Besides, the facile, bioinspired, osteopromotive modification strategy can be used in other orthopedic and dental implants, such as titanium, zirconium dioxide.
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