Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 29, Issue 11, Pages 1233-1249Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2018.1456024
Keywords
Cellulose; modification; controlled release
Funding
- National Natural Science Foundation of China [31570570]
- Program for Scientific Research Innovation Team in Colleges and Universities of Shandong Province
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Succinic anhydride (SAD) modified microcrystalline cellulose (MCC) films was prepared and used for the controlled release of the drug domperidone (dom). The morphology and chemical structure of the modified materials were characterized by SEM, FTIR, XRD and TG/DSC techniques. The physical properties, such as water uptake and swelling, light barrier properties, mechanical testing, in vitro degradation behavior, have been investigated. Results showed that the modified cellulose membranes exhibited good anti-UV properties, higher water uptake values, improved mechanical capacity and anti-biodegradability. In addition, the modified MCC films (MS) as the drug carrier indicated the controlled release of domperidone and the release mechanism was proposed using Korsmeyer-Peppas equation at pH 7.4. The developed drug delivery system possessed the profound significance in improving pharmacodynamics and bioavailability of drugs.
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