Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 29, Issue 12, Pages 1463-1481Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2018.1466469
Keywords
Polyvinyl alcohol (PVA); polyethylene glycol (PEG); nano-hydroxyapatite (n-HA); porous materials; biomaterials
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Polyvinyl alcohol (PVA) hydrogels have been widely studied for biomedical applications due to their water solubility, non-toxicity, non-carcinogenicity, and biocompatibility. However, PVA hydrogels prepared by the physical crosslinking method usually do not exhibit a macroporous structure, which limits their application when PVA hydrogels are used alone as a wound dressing. Here, we reported a sponge-like macroporous PVA hydrogel (SPH) prepared by employing polyethylene glycol and nano-hydroxyapatite (n-HA) to enhance phase separation. After being fabricated through cyclic freezing/thawing, the resulting PVA hydrogels possessed macroporous structures. The swelling ratio could reach nearly 1500%, resulting from the excellent water absorption capacity, and the sample could rapidly restore to the original state after being pressed, suggesting a sponge-like characteristic. Furthermore, cell experiments showed that macroporous PVA hydrogels exhibited good biocompatibility and the results of wound closure and H&E analysis consistently indicated that SPHs could significantly promote the wound healing process.
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