Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 293, Issue 27, Pages 10524-10535Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.TM118.000372
Keywords
genomic instability; DNA recombination; DNA repair; DNA topology; DNA damage; DNA endonuclease; DNA helicase; DNA polymerase; DNA topoisomerase
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Funding
- National Institutes of Health [GM58015, CA92276]
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Homologous recombination enables the cell to access and copy intact DNA sequence information in trans, particularly to repair DNA damage affecting both strands of the double helix. Here, we discuss the DNA transactions and enzymatic activities required for this elegantly orchestrated process in the context of the repair of DNA double-strand breaks in somatic cells. This includes homology search, DNA strand invasion, repair DNA synthesis, and restoration of intact chromosomes. Aspects of DNA topology affecting individual steps are highlighted. Overall, recombination is a dynamic pathway with multiple metastable and reversible intermediates designed to achieve DNA repair with high fidelity.
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