The short review on the studies of T cells receptors relate to type 1 diabetes

Although type 1 diabetes (T1D) is a common autoimmune disease, and there have been many experimental and clinical researches on it, yet the exact mechanisms still remain unclear. What is the fact without doubt that T cells play an important role in the progress of T1D. Because the identification of T cells depends on the identification of MHC which binds the peptides of auto-antigens, the responses of T cells specific to this combination might make the T cell receptor (TCR) genes changed, especially the complementarity determining region 3 (CDR3) genes. According to this theory, it is possible to unclose the immune mechanisms of T1D from the changes of the specific TCR. This paper focuses on the current studies of TCR relative to T1D. (C) 2014 Diabetes India. Published by Elsevier Ltd. All rights reserved.