Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 293, Issue 15, Pages 5386-5395Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R117.810366
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Funding
- Francis Crick Institute from Cancer Research UK [FC001187]
- UK Medical Research Council Grant [FC001187]
- Wellcome Trust Grant [FC001187]
- Cancer Research UK [15153] Funding Source: researchfish
- The Francis Crick Institute [10187] Funding Source: researchfish
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Autophagy is a highly conserved process and is essential for the maintenance of cellular homeostasis. Autophagy occurs at a basal level in all cells, but it can be up-regulated during stress, starvation, or infection. Misregulation of autophagy has been linked to various disorders, including cancer, neurodegeneration, and immune diseases. Here, we discuss the essential proteins acting in the formation of an autophagosome, with a focus on the ULK and VPS34 kinase complexes, phosphatidylinositol 3-phosphate effector proteins, and the transmembrane autophagy-related protein ATG9. The function and regulation of these and other autophagy-related proteins acting during formation will be addressed, in particular during amino acid starvation.
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