Journal
GENOMICS
Volume 105, Issue 5-6, Pages 253-264Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2015.01.008
Keywords
Age-related macular degeneration; cDNA microarray; Glaucoma; Retina; Retinal pigmented epithelium; Choroid; RNA-Seq; Serial analysis of gene expression; Transcriptome
Funding
- NEI [EY06109, EY023164, EY020483]
- Arnold and Mabel Beckman Initiative for Macular Research
- EyeSight Foundation of Alabama, Research to Prevent Blindness
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The retina and its adjacent supporting tissues - retinal pigmented epithelium (RPE) and choroid - are critical structures in human eyes required for normal visual perception. Abnormal changes in these layers have been implicated in diseases such as age-related macular degeneration and glaucoma. With the advent of high-throughput methods, such as serial analysis of gene expression, cDNA microarray, and RNA sequencing, there is unprecedented opportunity to facilitate our understanding of the normal retina, RPE, and choroid. This information can be used to identify dysfunction in age-related macular degeneration and glaucoma. In this review, we describe the current status in our understanding of these transcriptomes through the use of high-throughput techniques. (C) 2015 Elsevier Inc. All rights reserved.
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