Journal
JOURNAL OF ASTHMA
Volume 56, Issue 3, Pages 263-269Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/02770903.2018.1455853
Keywords
Biologic therapy; BMI trajectory; mepolizumab; omalizumab; uncontrolled pediatric asthma
Categories
Ask authors/readers for more resources
Objectives: Assess the relationship between inhaled corticosteroid use (ICS) and weight (BMI) in pediatric patients with moderate-severe asthma. Assess if the number of emergency department (ED) visits correlates with overall BMI trajectory. Assess the trend of prescribing biologic therapy in pediatric patients with moderate-severe asthma and determine its relationship with weight (BMI). Methods: A retrospective chart review was performed on 93 pediatric patients with moderate-severe asthma to determine the relationship between ICS use and weight (BMI), biologic therapy and BMI, and number of ED visits and BMI trajectory. A mixed effects model was employed with the correlation between repeated measures accounted for through the random effects. Results: There is a statistically significant increase of 0.369 kg/m(2) in BMI trajectory per year in subjects on high-dose steroids compared to an increase of 0.195 kg/m(2) in the low dose group (p < 0.05). The BMI of subjects initiated on biologic therapy (omalizumab or mepolizumab) had a statistically significant decrease in BMI trajectory of 0.818 kg/m(2) per year (p < 0.05). Subjects with >= 5 ED visits due to asthma exacerbations had a significantly higher BMI trajectory (p < 0.05). Conclusions: The potency of ICS use in pediatric patients with moderate-severe asthma affects BMI trajectory; the higher the dose, the greater the projected BMI increase per year. Initiation of biologic therapy decreased BMI trajectory over time. Lastly, those with frequent ED visits had a higher BMI trend. Future prospective studies are warranted that further evaluate the potential metabolic impacts of ICS and assess the effects of biologic therapy on BMI.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available