Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 21, Issue 2, Pages 178-185Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2018.1451521
Keywords
Mycophenolic acid; adenosine derivatives; antiproliferative activity; esterification
Funding
- Polish National Science Center (NCN) [2013/11/B/NZ7/04838]
Ask authors/readers for more resources
New conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2 ',3 '-O-isopropylidene protected and free hydroxyl groups possessing forms. The obtained results were also discussed in terms of selectivity index, defined as SI = IC50/EC50. [GRAPHICS] .
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available