Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 21, Issue 2, Pages 93-102Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2018.1450392
Keywords
Medicinal insect; Periplaneta americana; wound healing; nitric oxide
Funding
- National Science Fund for Distinguished Young Scholars [81525026]
- National Natural Science Foundation of China [81773606]
- Shenzhen Government's Plan of Science and Technology [JCYJ20170412110504956]
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Three new compounds, periplanamides A (1) and B (2), periplanpyrazine A (3), a new naturally occurring compound salicyluric acid methyl ester (6), and seventeen known compounds were isolated from the medicinal insect Periplaneta americana. The structures of the new compounds were elucidated on the basis of spectroscopic methods. The absolute configurations of 2 were assigned by computational methods. Biological activities of these isolates except 1, 9, 11, and 13 toward nitric oxide (NO) production, cell proliferation in HDFs, cell migration and angiogenesis in HUVECs were evaluated. [GRAPHICS] .
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