Journal
JOURNAL OF ASIA-PACIFIC ENTOMOLOGY
Volume 21, Issue 1, Pages 130-133Publisher
KOREAN SOC APPLIED ENTOMOLOGY
DOI: 10.1016/j.aspen.2017.11.009
Keywords
Juvenile hormone antagonist; Penfluridol; Aedes albopictus; Mosquitocidal activity
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Funding
- KOREA RESEARCH INSTITUTE of CHEMICAL TECHNOLOGY (KRICT) [SI1708]
- Brain Korea 21 plus project, Seoul National University, Republic of Korea
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Juvenile hormone antagonists (JHANs) are known to interfere with the formation of juvenile hormone (JH) receptor complex. JHANs might be effective for control of target pests in larval stages at which stages high level of endogenous JH titer is maintained. In order to identify novel insecticidal compounds, 2352 compounds were surveyed on their JHAN activities using the yeast-two hybrid system. Among 53 compounds with JHAN activities, penfluridol showed high level of insecticidal activity against larvae of Aedes albopictus. JHAN activity was increased in proportion to the concentration of penfluridol. Larvicidal activity of penfluridol was 1.3-2.0 folds higher than that of pyriproxyfen. These results suggested that penfluridol could be useful for control of mosquito larvae.
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