SYNTHESIS AND CHARACTERIZATION OF POLYMER BRUSHES CONTAINING β-CYCLODEXTRIN GRAFTED TO MAGNETIC NANOPARTICLES FOR DETERMINATION OF NAPROXEN IN URINE

beta-Cyclodextrin containing polymer brushes were grafted to magnetic nanoparticles following free radical copolymerization of N, N-dimethylacrylamide and allyl glycidyl ether on the surface. The products were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, elemental analysis, and transmission electron microscopy and employed for solid phase extraction of naproxen in human urine. The profile of the naproxen adsorbed by the nanoparticles demonstrated high accessibility of the beta-cyclodextrin. Scatchard analysis indicated that the capacity of the nanoparticles was 112 mu mol g(-1) at 25 degrees C and a pH of 5. The adsorption data of naproxen were considered by Langmuir, Freundlich, Redlich-Peterson, and Temkin isotherms. Approximately 55% of naproxen was released in simulated gastric fluid in 30 min and 94% in simulated intestinal fluid in 30 h. These data have indicated the utility of the naproxen loaded- beta-cyclodextrin containing polymer brushes grafted to magnetic nanoparticles for enteric drug delivery.