Journal
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
Volume 115, Issue 8, Pages 457-468Publisher
COMENIUS UNIV
DOI: 10.4149/BLL_2014_089
Keywords
glycemic control; overweight; obesity; diabetes mellitus; inflammation
Categories
Funding
- [VEGA 1-0375-09]
- [VEGA 1-0451-12]
- [UK/187/2011]
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Aim: In this study we tried to investigate the impact of glycemic control on parameters of glycation and inflammation in overweight and obese patients with type 2 diabetes mellitus. Patients and methods: Markers of glycation (HbA(1c), AGEs; measured by HPLC and spectrofluorimetry, resp.) and inflammatory markers (IL-6, IL-8, TNF-alpha, MCP-1; measured by xMAP technology) were assessed in 69 patients with T2DM, of whom 32 were patients were with poor glycemic control (PGC group), 37 patients were with good glycemic control (GGC group) and 23 were healthy blood volunteers. Results: Our results showed that plasma levels of fluorescent AGEs, IL-6, IL-8, TNF-alpha, and MCP-1 were significantly increased in PGC and GGC groups in comparison with control group, while the levels were higher in PGC group in comparison with GGC group, but the difference was not significant. We found a positive correlation between AGEs and MCP-1 and between TNF-alpha and creatinine in PGC group. We found significantly decreased levels of glycated HbA(1c) and AGEs in patients who used statins compared to patients who used fibrates. We observed beneficial impact of treatment with oral antidiabetic (OAD) agents + insulin on levels of IL-8, TNF-alpha and TAG in comparison with treatment with insulin alone. Conclusions: Despite good glycemic compensation of patients with T2DM, levels of AGEs and inflammatory markers remained significantly elevated in comparison with healthy controls. There was a beneficial impact of treatment with OAD agents + insulin in sense of lowering the low-grade inflammation (Tab. 3, Fig. 7, Ref. 113). Text in PDF www.elis.sk.
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