Journal
JOURNAL OF ANTIBIOTICS
Volume 71, Issue 7, Pages 619-625Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/s41429-018-0055-x
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Funding
- Institute for Fermentation Osaka (IFO), Japan
- JSPS KAKENHI [16H07167]
- Grants-in-Aid for Scientific Research [16H07167] Funding Source: KAKEN
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Two new compounds, designated as hamuramicins A (1) and B (2), were isolated from the cultured broth of an endophytic actinomycete Allostreptomyces sp. K12-0794 by silica gel column chromatography and HPLC. The structures of 1 and 2 were elucidated as 22-membered macrolide containing triene and trienone with an alkyl side chain by spectroscopic analyses including NMR experiments. Both compounds showed growth inhibition activity against Kocuria rhizophia and Xanthomonas oryzae pv. oryzae as well as human cell line toxicity.
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