Journal
JOURNAL OF ANTIBIOTICS
Volume 71, Issue 10, Pages 862-871Publisher
JAPAN ANTIBIOTICS RESEARCH ASSOC
DOI: 10.1038/s41429-018-0075-6
Keywords
-
Funding
- CONACyT [CB-219765, INFRA-252226, INFRA-205195]
- UNAM
- CONACyT
- [PAIP-UNAM 5000-9140]
- [CONACYT-0224747]
Ask authors/readers for more resources
From the rice-based culture of Malbranchea flavorosea, three new compounds namely flavoroseoside B (5-desoxy-5-chloroflavoroseoside) (2), 4-hydroxy-2-O-alpha-ribofuranosyl-5-methylacetophenone (3), and (S)-3,4-dihydro-3-(1H-indol-3-ylmethyl)- 4-methyl-1H-1,4-benzodiazepine-2,5-dione (4), along with three known compounds, rosigenin (5), massarilactone B (6), and riboxylarinol B (7) were obtained. The structures were determined by spectroscopic methods. Compound 4 and its synthetic analog 3,4-dihydro-3-(1H-indol-3-ylmethyl)-1-methyl-1H-1,4-benzodiazepine-2,5-dione (9) inhibited the activity of Ruminococus obeum alpha-glucosidase enzyme. Molecular docking and dynamic studies revealed that compounds 4 and 9 might bind to this a-glucosidase at the catalytic center. Phylogenetic analysis using internal transcribed spacer region revealed that Malbranchea flavorosea ATCC 34529 is related to Myxotrichum spp.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available