New phenolic bisabolane sesquiterpenoid derivatives with cytotoxicity from Aspergillus tennesseensis

Three new bisabolane sesquiterpenoid esters, aspertenols A-B (1-3), and six known compounds (4-9) were isolated from the fungus Aspergillus tennesseensis. The structures of new compounds were elucidated by extensive spectroscopic analysis. The cytotoxicities of 1-9 against A549, K562, and ASPC cell lines were tested by using the CCK8 method. Compounds 1, 3, 4, 6, 7, and 9 showed inhibition on K562 cell line with IC50 values in the range from 16.6 to 72.7 mu M. Compounds 1, 4, and 9 showed moderate inhibitory activity against A549 with IC50 of 43.5, 70.2, and 61.1 mu M, respectively.