Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 63, Issue 4, Pages 1261-1267Publisher
IOS PRESS
DOI: 10.3233/JAD-180107
Keywords
ABCA7; Alzheimer's disease; loss-of-function; meta-analysis
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Funding
- National Key R&D Program of China [2016YFC1305803]
- National Natural Science Foundation of China [81701253]
- Qingdao Key Health Discipline Development Fund
- Qingdao Outstanding Health Professional Development Fund
- Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders
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The ATP-binding cassette transporter A7 (ABCA7) was identified as a known risk factor for Alzheimer's disease (AD). However, the relation between ABCA7 and AD was still inconsistent across these studies. Here, our meta-analysis aimed at confirming the association of ABCA7 with AD. Finally, 16 case-control studies (63747 versus 85833) were retrieved from PubMed and other databases. Three common loci were confirmed to increase the risk of AD (rs3764650: OR = 1.20, 95% CI = 1.16-1.24; rs3752246: OR = 1.13,95% CI = 1.08-1.19; rs4147929: OR = 1.17, 95% CI = 1.10-1.24), but the associations varied among the different races. Furthermore, ABCA7 loss-of-function (LOF) mutations conferred a higher risk for AD than did the above variants (LOF: OR = 1.78, 95% = 1.43-2.22). In conclusion, ABCA7 genetic variants, especially the LOF mutations, were significantly associated with the risk of AD.
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