Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 63, Issue 4, Pages 1299-1305Publisher
IOS PRESS
DOI: 10.3233/JAD-170998
Keywords
Alzheimer's disease; physical activity; positron emission tomography; tau
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Funding
- NHMRC National Institute of Dementia Research [GNT1097105]
- CSIRO Flagship Collaboration Fund
- Science and Industry Endowment Fund (SIEF)
- Edith Cowan University (ECU)
- Florey Institute of Neuroscience and Mental Health
- Alzheimer's Australia (AA)
- National Ageing Research Institute (NARI)
- Austin Health
- CogState Ltd.
- Hollywood Private Hospital
- Sir Charles Gairdner Hospital
- National Health and Medical Research Council (NHMRC)
- Dementia Collaborative Research Centres program (DCRC2)
- Australian Alzheimer's Research Foundation, and Operational Infrastructure Support from the Government of Victoria
- CRC for Mental Health
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Numerous animal studies have reported exercise reduces the accumulation of Alzheimer's disease pathology, including amyloid-beta (A beta) and tau. Furthermore, we previously reported a relationship between higher levels of physical activity (PA) and lower brain A beta burden in a human population. The recent advent of tau positron emission tomography (PET) tracers enables us to extend our investigations into the evaluation of the relationship between PA and brain tau burden. Utilizing data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, we have examined the cross-sectional relationship between habitual PAand PET-quantified tau burden. Forty-three cognitively healthy older adults were categorized into low-moderate PA (LMPA; n = 16) or high PA (HPA; n = 27), based on self-reported PA levels. Tau PET imaging with the AV1451 tracer was conducted on all participants. The LMPA group had significantly higher neocortical tau burden (presented as a z-score; 1.22 +/- 1.98), compared to the HPA group (z-score: -0.28 +/- 1.18). The difference between the LMPA and HPA groups was also evident when examining regional tau burden in the temporoparietal cortex and the prefrontal cortex. Our results suggest an association between self-reported PA level and brain tau burden. Future longitudinal and interventional studies utilizing larger samples sizes are vital to further investigate the nature of the relationship between tau and PA.
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