Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume 64, Issue -, Pages S255-S270Publisher
IOS PRESS
DOI: 10.3233/JAD-179936
Keywords
AD risk; Alzheimer's disease; amyloid; obstructive sleep apnea; OSA phenotypes
Categories
Funding
- NIH/NIA/NHLBI [R21AG055002, R01HL118624, R01AG056031, R21AG049348, R01AG022374, R01AG056682, P30AG008051]
- Foundation for Research in Sleep Disorders
- American Sleep Medicine Foundation Junior Faculty Award
- American Thoracic Society Foundation
- Friedman Brain Institute
- NATIONAL INSTITUTE ON AGING [P30AG008051, R01AG056031, R21AG059179, R01AG056682, R21AG055002, R21AG049348] Funding Source: NIH RePORTER
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Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are highly prevalent conditions with growing impact on our aging society. While the causes of OSA are now better characterized, the mechanisms underlying AD are still largely unknown, challenging the development of effective treatments. Cognitive impairment, especially affecting attention and executive functions, is a recognized clinical consequence of OSA. A deeper contribution of OSA to AD pathogenesis is now gaining support from several lines of research. OSA is intrinsically associated with disruptions of sleep architecture, intermittent hypoxia and oxidative stress, intrathoracic and hemodynamic changes as well as cardiovascular comorbidities. All of these could increase the risk for AD, rendering OSA as a potential modifiable target for AD prevention. Evidence supporting the relevance of each of these mechanisms for AD risk, as well as a possible effect of AD in OSA expression, will be explored in this review.
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