Journal
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
Volume 3, Issue 11, Pages -Publisher
WILEY
DOI: 10.1038/psp.2014.45
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Funding
- Government of Canada - Natural Sciences and Engineering Research Council of Canada
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Increased regulatory demands for pediatric drug development research have fostered interest in the use of modeling and simulation among industry and academia. Physiologically based pharmacokinetic (PBPK) modeling offers a unique modality to incorporate multiple levels of information to estimate age-specific pharmacokinetics. This tutorial will serve to provide the reader with a basic understanding of the procedural steps to developing a pediatric PBPK model and facilitate a discussion of the advantages and limitations of this modeling technique.
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