Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 142, Issue 4, Pages 1113-+Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2018.05.012
Keywords
Allergy; Can f 1; Can f 2; Can f 3; Can f 4; Can f 5; Can f 6; children; dog; IgE; molecular allergology; nasal provocation test; sensitization
Categories
Funding
- Swedish Asthma and Allergy Association's Research Foundation
- Stockholm County Council (ALF project)
- Swedish Research Council
- Swedish Heart-Lung Foundation
- Swedish Cancer
- Allergy Foundation
- Hesselman foundation
- Konsul Th C Bergh foundation
- Karolinska Institutet
- Stockholm County Council (post-doc)
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Background: Sensitization to dog dander is an important risk factor for rhinoconjunctivitis and asthma but is not sufficient for diagnosing dog allergy. Molecular allergy diagnostics offer new opportunities for refined characterization. Objectives: We sought to study the association between sensitization to all presently known dog allergen components and clinical symptoms of dog allergy in children evaluated by using nasal provocation tests (NPTs). Methods: Sixty children (age, 10-18 years) sensitized to dog dander extract underwent NPTs with dog dander extract. Measurement of IgE levels to dog dander and to Can f 1, Can f 2, Can f 3, and Can f 5 was performed with ImmunoCAP, and measurement of IgE levels to Can f 4 and Can f 6 was performed with streptavidin ImmunoCAP. An IgE level of 0.1 kU(A)/L or greater was considered positive. Results: There was an association between sensitization to an increasing number of dog allergen components and a positive nasal challenge result (P = .01). Sensitization to lipocalins (odds ratio [OR], 6.0; 95% CI, 1.04-34.5), in particular Can f 4 (OR, 6.80; 95% CI 1.84-25.2) and Can f 6 (OR, 5.69; 95% CI, 1.59-20.8), was associated with a positive NPT result. Monosensitization to Can f 5 was related to a negative NPT result (OR, 5.78; 95% CI, 1.01-33.0). Conclusion: Sensitization to an increasing number of dog allergen components and to lipocalins is associated with dog allergy. Monosensitization to Can f 5 should not be regarded primarily as a marker for dog allergy.
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