Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 141, Issue 1, Pages 30-40Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2017.11.010
Keywords
Food allergy; peanut allergy; egg allergy; allergy prevention
Categories
Funding
- National Institute of Allergy and Infectious Diseases (NIAID, NIH)
- Food Allergy & Research Education (FARE)
- MRC & Asthma UK Centre
- UK Department of Health through NIHR
- National Peanut Board (NPB)
- UK Food Standards Agency (FSA)
- National Institute of Allergy and Infectious Diseases [AI-44236]
- NIH AITC Review Panel
- Allertein
- American Society for Microbiology
- Elsevier
- FARE
- World Allergy Organization
- Adept Field Solutions
- Aimmune Therapeutics, Inc
- Astellas Pharma Global Development, Inc
- Biomerica, Inc
- Evelo Biosciences, Inc/Epiva Biosciences, Inc
- First Manhattan Co
- Genentech
- GLG Research, Inc
- Insys Therapeutics
- Intrommune Therapeutics
- PPD Development, LP
- Regeneron Pharmceuticals, Inc
- Sanofi US Services
- SRA International
- Stallergenes
- UKKO, Inc
- Valeant Pharmaceuticals North America, LLC
- Food Allergy Research and Education (FARE)
- National Institutes of Health
- Wallace Research Foundation
- Actellion
- European Union project Medall
- Allergopharma
- Swiss National Science Foundation
- Christine Kuhne Center for Allergy Research and Education
- National Institutes of Allergy and Infectious Diseases [NO1-AI-15416, UM1AI109565]
- UK Department of Health through the National Institute for Health Research
- National Peanut Board
- Osem
- European Union project Predicta
Ask authors/readers for more resources
Of the many possible hypotheses that explain the recent increase in childhood food allergy (FA), the dual-allergen exposure hypothesis has been the most extensively investigated. This chapter serves as a review and update on the prevention of FA and focuses on recently published randomized controlled trials exploring the efficacy of oral tolerance induction in infancy for the prevention of FA. As a result of these RCTs, National Institutes of Health recommendations now actively encourage the early introduction of peanut for the prevention of peanut allergy, and other countries/settings recommend the inclusion of potential common food allergens, including peanut and egg, in complementary feeding regimens commencing at approximately 6 months but not before 4 months of age. Further studies that explore the efficacy of oral tolerance induction to other common food allergens and that focus on optimal timing, duration, and adherence are required.
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