Journal
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Volume 141, Issue 2, Pages 491-498Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jaci.2017.12.979
Keywords
Oral immunotherapy; immune mechanisms; desensitization; sustained unresponsiveness; basophils; T cells; B cells; mast cells; antibodies
Categories
Funding
- National Institutes of Health (NIH)
- Sanofi
- American Academy of Allergy, Asthma & Immunology Foundation
- Food Allergy Research & Education (FARE)
- National Institute of Allergy and Infectious Diseases (NIAID)
- Astellas
- Aimmune
- Anaptys Bio
- Immune Tolerance Network
- Aimmune Therapeutics
- NIH/NIAID
- FARE
- American College of Allergy, Asthma Immunology
Ask authors/readers for more resources
Oral immunotherapy (OIT) has demonstrated reproducibly successful desensitization in patients with food allergy completing clinical trials and, in some studies, sustained unresponsiveness. These clinical outcomes have been associated with characteristic modifications in the allergen-specific immune response, but a detailed synthesis of OIT's mechanisms of action is lacking. In this rostrum we review the current evidence regarding the human immune response to OIT, explore possible mechanisms, and identify knowledge gaps for future research.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
