Journal
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Volume 44, Issue 11, Pages 2742-2754Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-014-2131-9
Keywords
Diffusion MRI; ADHD; ASD; White matter; Tract-based spatial statistics; RESTORE
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Funding
- Medical Research Council [MR/L010305/1] Funding Source: Medline
- Wellcome Trust [096646] Funding Source: Medline
- Medical Research Council [MR/L010305/1] Funding Source: researchfish
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Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD(n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p < 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case-control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD.
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