Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 66, Issue 12, Pages 3146-3154Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b00287
Keywords
Mushroom; Macrolepiota procera; lanostane triterpenoid; anti-inflammatory activity; cytotoxicity
Funding
- National Natural Science Foundation of China [31560010, 81561148013]
- Key Projects of Technological Innovation of Hubei Province [2016ACA138]
- Fundamental Research Funds for the Central Universities
- South-Central University for Nationalities [CZW17094, CZY16010, CSP17061, CZQ17008]
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This study features the isolation and identification of 12 lanostane-type triterpenoids, namely lepiotaprocerins A-L, 1-12, from the fruiting bodies of the Poland-collected edible mushroom Macrolepiota procera. The structures and the absolute configurations of the new compounds were ambiguously established by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analyses. Structurally, lepiotaprocerins A-F, 1-6, are distinguished by the presence of a rare 1-en-1,11-epoxy moiety which has not been previously described in the lanostane class. Biologically, lepiotaprocerins A-F, 1-6, displayed more significant inhibitions of nitric oxide (NO) production than the positive control L-N-G-monomethyl arginine (L-NMMA) (IC50 47.1 mu M), and lepiotaprocerins G-L, 7-12, showed various cytotoxicity potencies against a panel of human cancer cell lines. Compound 9 also displayed antitubercular activity against Mycobacterium tuberculosis H37Ra with a minimal inhibitory concentration (MIC) 50 mu g/mL.
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