Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 66, Issue 9, Pages 2083-2091Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.7b05719
Keywords
seleno-polymannuronate; lipopolysaccharide; anti-inflammation; nuclear factor kappa B; mitogen-activated protein kinase
Funding
- Science and Technology Innovation Commission of Shenzhen [JCYJ20170302144535707, JSGG20160229120821300]
- National Natural Science Foundation of China [31000770, 31470804, 31540012]
- Science and Technology Planning Project of Guangdong Province [2014A020212488]
- Yangzhou University Innovation Fund [2014CXJ032]
- Natural Science Foundation of Jiangsu Province [BK20141276]
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Alginate-derived polymannuronate (PM) is a type of polysaccharide found in edible brown seaweeds. Seleno-polymannuronate (Se-PM) was prepared from PM via synthesis using sulfation- and selenation-replacement reactions. The anti-inflammatory activity of Se-PM and its corresponding molecular mechanisms were investigated. In lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells, Se-PM significantly attenuated the production of nitric oxide (NO), prostaglandin E-2 (PGE(2)), and reactive oxygen species (ROS); the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2); and the secretion of proinflammatory cytokines. Moreover, Se-PM remarkably suppressed the LPS-induced activation of the nuclear-factor (NF)-kappa B and mitogen-activated-protein-kinase (MAPK) signaling pathways in RAW264.7 cells. Furthermore, Se-PM also decreased the production of proinflammatory mediators in LPS-triggered primary murine macrophages. Additionally, Se-PM inhibited the inflammatory response in the air-pouch inflammation model. These results might contribute to the overall understanding of the potential health benefits of Se-PM for food and drug applications.
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