Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 66, Issue 16, Pages 4164-4170Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b00961
Keywords
honey bee; Apis mellifera; royal jelly; MRJP; pepsin; trypsin; chymotrypsin
Funding
- ManukaMed Limited Partnership (MMLP, Masterton, New Zealand)
- German Research Foundation (Deutsche Forschungsgemeinschaft - DFG) [MO 373/32-1]
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Royal jelly (RJ) is a beehive product with a complex composition, major royal jelly proteins (MRJPs) being the most abundant proteins. Cell culture and animal studies suggest various biological activities for the full-length/native MRJPs. In the field of apitherapy, it is assumed that MRJPs can positively affect human health. However, whenever RJ is administered orally, the availability for assimilation in the gastrointestinal tract is a prerequisite for MRJPs to have any effect on humans. We here show that MRJPs vary in resistance to pepsin digestion with MRJP2 being most stable and still present as full-length protein after 24 h of digestion. In the intestinal phase, using trypsin and chymotrypsin, MRJPs are rapidly digested with MRJP2 again showing longest stability (40 min), suggesting that MRJPs can reach the small intestine as full-length proteins but then have to be resorbed quickly if full-length proteins are to fulfill any biological activity.
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