Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 66, Issue 15, Pages 3966-3974Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.8b00427
Keywords
pesticide residues; isomer quantitation; limit of detection; MALDI; high-resolution FTICR-MS
Funding
- National Natural Science Foundation of China [31672044]
- Natural Science Foundation of Guangdong Province [2014A030311044, 2016A030313387]
- Science and Technology Program of Guangzhou [201707020013]
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Matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry (MALDI-FTICR-MS) has been applied for rapid, sensitive, undisputed, and quantitative detection of pesticide residues on fresh leaves with little sample pretreatment. Various pesticides (insecticides, bactericides, herbicides, and acaricides) are detected directly in the complex matrix with excellent limits of detection down to 4 mu g/L. FTICR-MS could unambiguously identify pesticides with tiny mass differences (similar to 0.017 75 Da), thereby avoiding false-positive results. Remarkably, pesticide isomers can be totally discriminated by use of diagnostic fragments, and quantitative analysis of pesticide isomers is demonstrated. The present results expand the horizons of the MALDI-FTICR-MS platform in the reliable determination of pesticides, with integrated advantages of ultrahigh mass resolution and accuracy. This method provides growing evidence for the resultant detrimental effects of pesticides, expediting the identification and evaluation of innovative pesticides.
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