Journal
ACTA VIROLOGICA
Volume 58, Issue 2, Pages 103-107Publisher
AEPRESS SRO
DOI: 10.4149/av_2014_02_103
Keywords
human cytomegalovirus; UL128 gene/protein; chemokine
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Funding
- National Natural Science Foundation of China [81071337, 81200486]
- Natural Science Foundation of Zhejiang Province [Z2110006]
- Education Department of Zhejiang Province [Y201017974]
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Human cytomegalovirus (HCMV) ORF UL128 protein is highly conserved among viral field isolates and functions in two different molecular forms, monomeric UL128 protein and in a complex with glycoproteins gH, gL, UL130, and UL131A protein. Monomeric UL128 protein works as soluble chemokine analogue to attract peripheral blood mononuclear cells (PBMCs) and selectively induces expression of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) in PBMCs. The gH/gL/UL128/UL130/UL131A complex is indispensable for entry into both endothelial and epithelial cells. In conclusion, UL128 plays an important role in HCMV infection.
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