Journal
JOURNAL OF AFFECTIVE DISORDERS
Volume 234, Issue -, Pages 351-357Publisher
ELSEVIER
DOI: 10.1016/j.jad.2017.11.015
Keywords
Major Depressive Disorder (MDD); Genetics; Clock genes
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Background: Circadian rhythms are largely dysregulated in Major Depressive Disorder (MDD). The present review provides a summary of the findings about the role of clock genes in the etiology of MDD. Methods: A careful search of articles on Pubmed, PsycINFO, Isi Web of Knowledge was performed in order to obtain a comprehensive review about the topic. Results: The studies reported contrasting results about the association of different single nucleotide poly-morphisms (SNPs) in clock genes and MDD. The most consistent result reported the association between SNP rs2287161 of CRY1 and MDD development. Limitations: Most of the published papers on the topic show bias as a prevalence of Asian ethnicity or not blinded conditions of laboratory experiments with respect to subjects' conditions (healthy controls or MDD). Conclusion: Further epigenetic and genome-wide studies are necessary to have a more clear idea about the role of clock genes in the etiology of MDD.
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