Journal
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
Volume 16, Issue 6, Pages 685-693Publisher
WILEY
DOI: 10.1111/ddg.13529
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [NSFC 81360236]
- Shanghai Hospital Development Center project [SHDC12014217]
- Shanghai Committee of Science and Technology, China [16411961500]
- National Research, Development and Innovation Fund (Hungarian NRDIF) [K 120206]
- European Union under the European Regional Development Fund
- [GINOP-2.3.2-15-2016-00005]
Ask authors/readers for more resources
Herpes simplex virus (HSV)-1 and -2 infections are highly prevalent worldwide. HSV infection during pregnancy can result in neonatal herpes infection, which is characterized by lifelong infection with periods of latency and reactivation. HSV can be acquired by an infant during one of three periods: in utero (5 %), peripartum (85 %), or postnatal (10 %). Neonatal HSV is a rare but significant infection that may be associated with severe morbidity and mortality, especially if there is dissemination or central nervous system involvement. Diagnostic and therapeutic advances have led to a reduction in mortality and, to a lesser extent, improvement of neurodevelopmental outcomes, but further developments are still needed. It is essential to improve the clinician's ability to identify infants who are at increased risk of HSV infection and to prevent mother-to-child transmission. The development of novel antiviral agents with higher efficacy is a worthwhile aim for the future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available