Journal
JORNAL DE PEDIATRIA
Volume 95, Issue 2, Pages 247-254Publisher
SOC BRASIL PEDIATRIA
DOI: 10.1016/j.jped.2018.01.002
Keywords
Atherosclerosis; Cohort study; Inflammation; Pervention
Categories
Funding
- Academy of Finland [117787, 121584, 126925, 124282, 129378, 41071]
- Social Insurance Institution of Finland
- Turku University Foundation
- Kuopio University Hospital Medical Fund
- Tampere University Hospital Medical Fund
- Turku University Hospital Medical Fund
- Special Federal Grants for University Hospitals
- Juho Vainio Foundation
- Paavo Nurmi Foundation
- Finnish Foundation of Cardiovascular Research
- Orion-Farmos Research Foundation
- Finnish Cultural Foundation
- Finnish Centre of Excellence in Cardiovascular and Metabolic Disease
- National Heart Foundation of Australia Future Leader Fellowship [100849]
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Objective: Secretory phospholipase A2 (sPLA2) enzyme activity is a potential inflammatory biomarker for cardiovascular disease. We examined the tracking, or persistence, of sPLA2 enzyme activity levels from childhood to adulthood, and identify potentially modifiable factors affecting tracking. Method: Prospective cohort of 1735 children (45% females) who had serum sPLA2 enzyme activity levels and other cardiovascular disease risk factors measured in 1980 that were followed-up in 2001. Results: sPLA2 activity tracked from childhood to adulthood for males (r =0.39) and females (r =0.45). Those who decreased body mass index relative to their peers were more likely to resolve elevated childhood sPLA2 levels than have persistent elevated sPLA2 levels in childhood and adulthood. Those who consumed less fruit, and gained more body mass index relative to their peers, began smoking or were a persistent smoker between childhood and adulthood were more likely to develop incident elevated sPLA2 levels than those with persistent not elevated sPLA2 levels. Conclusions: Childhood sPLA2 enzyme activity levels associate with adult sPLA2 levels 21 years later. Healthful changes in modifiable risk factors that occur between childhood and adulthood might prevent children from developing elevated sPLA2 levels in adulthood. (C) 2019 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda.
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