Journal
ISME JOURNAL
Volume 12, Issue 9, Pages 2330-2334Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41396-018-0183-0
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Funding
- Danish Council for Independent Research [11106571]
- Danish Innovation Consortium [11804520]
- ITN Marie-Curie grant [289949]
- AUFF NOVA [AUFF-E-2016-9-38]
- Humboldt Research Fellowship for postdocs
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The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative plasmid transfer rates.
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