Journal
GENETICS AND MOLECULAR RESEARCH
Volume 14, Issue 2, Pages 3570-3578Publisher
FUNPEC-EDITORA
DOI: 10.4238/2015.April.17.6
Keywords
Bovine mastitis; NOD2 gene; Somatic cell score
Funding
- Sichuan Provincial Key Laboratory of Animal Breeding and Genetics
- Sichuan Animal Science Academy
- National 11th Five-Year Technology based Plan Topic [2006BAD04A17]
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The NOD2 gene plays a fundamental role in initiating the inflammatory and subsequent immune response. NOD2 was previously identified as a susceptibility locus for inflammatory bowel diseases in humans. In this study, we detected 2 mutations in exon 12 (A -> T, G -> A) among 5 cattle breeds (N = 315) and analyzed their associations with production traits and genetic resistance against bovine mastitis in Chinese Holstein and Chinese Simmental breeds (N = 218). The transitions (A -> T) at position 114 bp were associated with somatic cell score (P < 0.01). The G -> A at position 1594 bp plays a critical role in increasing 305-day milk yields. In Chinese Holstein and Chinese Simmental breeds, the BB genotype may contribute to disease susceptibility. Compared to all genotypic combinations, the A, B, andFF genotypes are beneficial not only for reducing somatic cell score but also for increasing production.
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