Journal
GENETICS
Volume 200, Issue 4, Pages 1021-1028Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.115.176370
Keywords
synthetic biology; ethics; governance; oversight; yeast
Categories
Funding
- Direct For Biological Sciences [1443299] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience [1445537] Funding Source: National Science Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007814] Funding Source: NIH RePORTER
- NIGMS NIH HHS [T32 GM007814] Funding Source: Medline
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First introduced in 2011, the Synthetic Yeast Genome (Sc2.0) Project is a large international synthetic genomics project that will culminate in the first eukaryotic cell (Saccharomyces cerevisiae) with a fully synthetic genome. With collaborators from across the globe and from a range of institutions spanning from do-it-yourself biology (DIYbio) to commercial enterprises, it is important that all scientists working on this project are cognizant of the ethical and policy issues associated with this field of research and operate under a common set of principles. In this commentary, we survey the current ethics and regulatory landscape of synthetic biology and present the Sc2.0 Statement of Ethics and Governance to which all members of the project adhere. This statement focuses on four aspects of the Sc2.0 Project: societal benefit, intellectual property, safety, and self-governance. We propose that such project-level agreements are an important, valuable, and flexible model of self-regulation for similar global, large-scale synthetic biology projects in order to maximize the benefits and minimize potential harms.
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