Journal
GENETICS
Volume 199, Issue 3, Pages 841-+Publisher
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.114.173807
Keywords
coalescent; multiple mergers; population growth; approximate maximum likelihood test; approximate Bayesian computation; sitefrequency spectrum
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Funding
- Deutsche Forschungsgemeinschaft (DFG) [BL 1105/3-1]
- DFG, SPP Priority Programme [BI 1058/2-1, 1590]
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The ability of the site-frequency spectrum (SFS) to reflect the particularities of gene genealogies exhibiting multiple mergers of ancestral lines as opposed to those obtained in the presence of population growth is our focus. An excess of singletons is a wellknown characteristic of both population growth and multiple mergers. Other aspects of the SFS, in particular, the weight of the right tail, are, however, affected in specific ways by the two model classes. Using an approximate likelihood method and minimum-distance statistics, our estimates of statistical power indicate that exponential and algebraic growth can indeed be distinguished from multiplemerger coalescents, even for moderate sample sizes, if the number of segregating sites is high enough. A normalized version of the SFS (nSFS) is also used as a summary statistic in an approximate Bayesian computation (ABC) approach. The results give further positive evidence as to the general eligibility of the SFS to distinguish between the different histories.
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