Journal
META GENE
Volume 2, Issue -, Pages 782-798Publisher
ELSEVIER
DOI: 10.1016/j.mgene.2014.10.003
Keywords
Visceral leishmaniasis; Apical Membrane Antigen 1; A2 gene family; Amastin; Species specific genes
Categories
Funding
- Ministry of Human Resource Development, Government of India
Ask authors/readers for more resources
Comparative genome analysis of recently sequenced Leishmania (L.) donovani was unexplored so far. The present study deals with the complete scanning of L. (L.) donovani genome revealing its interspecies variations. 60 distinctly present genes in L. (L.) donovani were identified when the whole genome was compared with Leishmania (L.) infantum. Similarly 72, 159, and 265 species specific genes were identified in L. (L.) donovani when compared to Leishmania (L.) major, Leishmania (L.) mexicana and Leishmania (Viannia) braziliensis respectively. The cross comparison of L. (L.) donovani in parallel with the other sequenced species of leishmanial led to the identification of 55 genes which are highly specific and expressed exclusively in L. (L.) donovani. We found mainly the discrepancies of surface proteins such as amastins, proteases, and peptidases. Also 415 repeat containing proteins in L. (L.) donovani and their differential distribution in other leishmanial specieswere identified which might have a potential role during pathogenesis. The genes identified can be evaluated as drug targets for anti- leishmanial treatment, exploring the scope for extensive future investigations. (C) 2014 The Authors. Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available