Journal
ENDOCRINOLOGY AND METABOLISM
Volume 29, Issue 4, Pages 522-529Publisher
KOREAN ENDOCRINE SOC
DOI: 10.3803/EnM.2014.29.4.522
Keywords
Cardiovascular diseases; Metabolic syndrome; Coronary disease; Stroke; Sex
Categories
Funding
- National Genome Research Institute
- Korean Center for Disease Control and Prevention [2001similar to2003-348-6111-221, 2004-347-6111-213, 2005-347-2400-2440-215]
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Background: Metabolic syndrome (MetS) is a condition characterized by a cluster of metabolic disorders and is associated with increased risk of cardiovascular disease (CVD). This study analyzed data from the Korean Health and Genome Study to examine the impact of MetS on CVD. Methods: A total of 8,898 subjects (4,241 males and 4,657 females), 40 to 69 years of age, were enrolled and evaluated for the development of new onset CVD from 2001 to 2012 (median 8.1 years of follow-up). Results: The prevalence of MetS at baseline was 22.0% (932/4,241) and 29.7% (1,383/4,657) in males and females, respectively. MetS was associated with increased risk of coronary heart disease (CHD; hazard ratio [HR], 1.818; 95% confidence interval [CI], 1.312 to 2.520 in males; HR, 1.789; 95% CI, 1.332 to 2.404 in females) and CVD (HR, 1.689; 95% CI, 1.295 to 2.204 in males; HR, 1.686; 95% CI, 1.007 to 2.192 in females). Specifically, MetS was associated with risk of future stroke in females only (HR, 1.486; 95% CI, 1.007 to 2.192). Among MetS components, abdominal obesity and hypertension were independent predictors of both CHD and CVD. In addition, a higher number of MetS components correlated with higher CVD risk. Conclusion: MetS is a significant risk factor for the development of CVD although its impact varies between sexes.
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