Journal
NEURO-ONCOLOGY PRACTICE
Volume 1, Issue 4, Pages 178-183Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nop/npu023
Keywords
CCNU; glioma; lomustine; myelosuppression; overdose; PCV
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Lomustine is an oral alkylating drug commonly used for brain tumor patients. Recently, the lomustine-containing PCV polychemotherapy regime (procarbazine, CCNU/lomustine, and vincristine) in combination with radiotherapy has become the standard of care for anaplastic oligodendroglioma with 1p/19q codeletion and high-risk low-grade glioma. Here, we review the literature of all reported cases of lomustine overdose, highlight complications by exemplifying a case of inadvertent lomustine overdose, and outline the management of this potential complication of outpatient PCV therapy.
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