Journal
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
Volume 94, Issue 3, Pages 212-228Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09553002.2018.1422871
Keywords
Chronic fatigue syndrome; bystander effects of radiation; reactive oxygen species (ROS); post-radiation syndrome; atomic veterans
Funding
- CFIDS Foundation Inc.
Ask authors/readers for more resources
Purpose: To investigate biochemical pathways known to be involved in radiation response and in CFIDS to determine if there might be common underlying mechanisms leading to symptoms experienced by those accidentally or deliberately exposed to radiation and those suffering from CFIDS. If such a link was established to suggest testable hypotheses to investigate the mechanisms with the aim of identifying new therapeutic targets.Conclusions: Evidence for involvement of the alpha-synuclein, cytochrome c oxidase, B-crystallin, RNase L, and lactate dehydrogenase/STAT1 pathways is strong and suggests a common underlying mechanism involving mitochondrial dysfunction mediated by ROS and disruption of ATP production. The downstream effect of this is compromised energy production. Testable hypotheses are suggested to investigate the involvement of these pathways further.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available