Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 68, Issue 4, Pages 208-215Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2018.1443927
Keywords
Antioxidants; biocompatible polymers; chitosan; collagen; ellagic acid; ROS
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In this study, chitosan and collagen based scaffolds loaded with ellagic acid were synthesized with an aim to incorporate antioxidant properties within the supporting matrix. Structural characterization of the scaffolds by X-ray diffraction and Fourier transform infrared spectroscopy confirmed the presence of ellagic acid within the chitosan-collagen matrix. The 'fabricated' scaffolds exhibited sustained release of ellagic acid in phosphate buffered saline for 120 h. The scaffolds were biocompatible and supported the recovery of COS 7 cells from the oxidative stress arising due to UV irradiation. Such antioxidant incorporated scaffolds present a potential approach in managing chronic wounds by eliminating ROS. [GRAPHICS]
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