Journal
INTERNATIONAL JOURNAL OF NEUROSCIENCE
Volume 128, Issue 12, Pages 1180-1187Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/00207454.2018.1481065
Keywords
S-100 beta; stroke; diagnosis; prognosis
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Funding
- Chongqing General Hospital [CGHK201701]
- Natural Science Foundation of Hubei Province [2015CFB260]
- Hubei Province Health and Family Planning Scientific Research Project [WJ2015MB219]
- Shiyan Natural Science Foundation [15K70]
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The S-100 beta levels are associated with a variety of acute disorders and other chronic diseases, such as head injury, stroke, metastatic melanoma, cardiac surgery, bone fractures, burns and contusions. The serum S-100 beta levels seem to increase with the volume of tissue damage. Higher serum S-100 beta levels have been observed after brain damage or stroke. A number of studies have evidenced the clinical value of S-100 beta in the diagnosis and prognosis of stroke while the S-100 beta marker is elevated in the peripheral blood during the acute phase of stroke. However, the clinical usefulness of S-100 beta biomarker in the diagnosis and prognosis of stroke has a limitation due to its low discriminating ability in stroke diagnosis and prognosis.
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