Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 13, Issue -, Pages 3311-3327Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S165125
Keywords
antibacterial mechanism; biocompatibility; osteogenic-related cells; orthopedic implants; silver nanoparticles; surface modification
Funding
- National Natural Science Foundation of China [81772456, 51627805]
- Norman Bethune Program of Jilin University [2012216]
- Science and Technology Development program of Jilin province [20150414006GH, 20170520120JH]
- Special fund project of Jilin provincial industrial innovation [2016C037]
- Training Program of Outstanding Doctoral Student by Norman Bethune Health Science Center of Jilin University [YB201501]
- Graduate Innovation Fund of Jilin University [2017089]
Ask authors/readers for more resources
Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available