Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/ijms19072043
Keywords
mTOR; metabolic diseases; glucose and lipid metabolism
Funding
- National Natural Science Foundation of China [81500619, 81730020]
- National Key R&D Program of China [2017YFC0908900]
- Natural Science Foundation of Guangdong Province [2016A030310040]
- Shenzhen Science and Technology Project [JCYJ20160422091658982, JCYJ20150324140036854]
- Shenzhen Peacocok Plan [KQTD20140630100746562, 827-000107]
- Natural Science Foundation of SZU [201567]
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The mammalian target of rapamycin, mTOR is the master regulator of a cell's growth and metabolic state in response to nutrients, growth factors and many extracellular cues. Its dysregulation leads to a number of metabolic pathological conditions, including obesity and type 2 diabetes. Here, we review recent findings on the role of mTOR in major metabolic organs, such as adipose tissues, liver, muscle, pancreas and brain. And their potentials as the mTOR related pharmacological targets will be also discussed.
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