Journal
GENES CHROMOSOMES & CANCER
Volume 55, Issue 2, Pages 120-123Publisher
WILEY-BLACKWELL
DOI: 10.1002/gcc.22316
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Funding
- Swedish Research Council
- Swedish Cancer Society
- Swedish Childhood Cancer Foundation
- Gunnar Nilsson Cancer Foundation
- Crafoord Foundation
- Strategic Cancer Research Program Bio-CARE
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Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal tumor. Two recurrent genetic aberrations have been described in CCSK. One is a fusion of YWHAE and NUTM2B/E, the other is an internal tandem duplication (ITD) in the BCOR gene. Here it is shown that YWHAE-NUTM2B/E fusion and the BCOR ITD are mutually exclusive events and activated different downstream signaling systems. This has important diagnostic implications and opens up for further mechanistic studies of CCSK pathogenesis. (C) 2015 Wiley Periodicals, Inc.
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