Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/ijms19051361
Keywords
malaria; curcumin; nanomedicine; oral administration; lipid nanovesicles; Eudragit; Nutriose; hyaluronan; Plasmodium yoelii
Funding
- Ministerio de Economia y Competitividad (MINECO), Spain [BIO2014-52872-R]
- Generalitat de Catalunya, Spain [2014-SGR-938]
- European Commission under Horizon's Marie Sklodowska-Curie Actions COFUND scheme [712754]
- MINECO's Severo Ochoa programme [SEV-2014-0425]
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Curcumin is an antimalarial compound easy to obtain and inexpensive, having shown little toxicity across a diverse population. However, the clinical use of this interesting polyphenol has been hampered by its poor oral absorption, extremely low aqueous solubility and rapid metabolism. In this study, we have used the anionic copolymer Eudragit((R)) S100 to assemble liposomes incorporating curcumin and containing either hyaluronan (Eudragit-hyaluronan liposomes) or the water-soluble dextrin Nutriose((R)) FM06 (Eudragit-nutriosomes). Upon oral administration of the rehydrated freeze-dried nanosystems administered at 25/75 mg curcumin center dot kg(-1)center dot day(-1), only Eudragit-nutriosomes improved the in vivo antimalarial activity of curcumin in a dose-dependent manner, by enhancing the survival of all Plasmodium yoelii-infected mice up to 11/11 days, as compared to 6/7 days upon administration of an equal dose of the free compound. On the other hand, animals treated with curcumin incorporated in Eudragit-hyaluronan liposomes did not live longer than the controls, a result consistent with the lower stability of this formulation after reconstitution. Polymer-lipid nanovesicles hold promise for their development into systems for the oral delivery of curcumin-based antimalarial therapies.
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