Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/ijms19041048
Keywords
melanoma; melanins; Bomirski hamster melanoma; ocular melanoma; human melanoma; X-rays; neutrons; proton beam irradiation; radio-chelation therapy; radio-photo-therapy; chemo-radiotherapy; tumor vessels
Funding
- Polish National Science Centre [UMO-2012/07/B/NZ4/01657]
- Ministry of Science and Higher Education [35p/10/2015]
- NIH [1R01AR056666-01A2, R21AR066505, 1R01AR071189-01A1]
- National Science Centre, Poland [2014/15/B/NZ4/00751]
Ask authors/readers for more resources
The focus of the present review is to investigate the role of melanin in the radioprotection of melanoma and attempts to sensitize tumors to radiation by inhibiting melanogenesis. Early studies showed radical scavenging, oxygen consumption and adsorption as mechanisms of melanin radioprotection. Experimental models of melanoma in hamsters and in gerbils are described as well as their use in biochemical and radiobiological studies, including a spontaneously metastasizing ocular model. Some results from in vitro studies on the inhibition of melanogenesis are presented as well as radio-chelation therapy in experimental and clinical settings. In contrast to cutaneous melanoma, uveal melanoma is very successfully treated with radiation, both using photon and proton beams. We point out that the presence or lack of melanin pigmentation should be considered, when choosing therapeutic options, and that both the experimental and clinical data suggest that melanin could be a target for radiosensitizing melanoma cells to increase efficacy of radiotherapy against melanoma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available