4.7 Review

Crosstalk between Notch, HIF-1α and GPER in Breast Cancer EMT

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner

Andrea L. Frump et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

Review Cell Biology

Physiological functions of FBW7 in cancer and metabolism

Kouhei Shimizu et al.

CELLULAR SIGNALLING (2018)

Review Cell Biology

Notch after cleavage

Sarah J. Bray et al.

CURRENT OPINION IN CELL BIOLOGY (2018)

Article Cell Biology

Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics

Maria J. Gomez-Lamarca et al.

DEVELOPMENTAL CELL (2018)

Review Biochemistry & Molecular Biology

Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives

Matthias Barton et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2018)

Review Biochemistry & Molecular Biology

GPER is involved in the functional liaison between breast tumor cells and cancer-associated fibroblasts (CAFs)

Rosamaria Lappano et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

IL6 blockade potentiates the anti-tumor effects of γ-secretase inhibitors in Notch3-expressing breast cancer

Dong Wang et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Oncology

The interplay between the cellular hypoxic response and Notch signaling

Sebastian K. -J. Landor et al.

EXPERIMENTAL CELL RESEARCH (2017)

Article Biochemistry & Molecular Biology

Involvement of Notch1 signaling in malignant progression of A549 cells subjected to prolonged cadmium exposure

Kota Fujiki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Review Physiology

NOTCH SIGNALING IN DEVELOPMENT, TISSUE HOMEOSTASIS, AND DISEASE

Chris Siebel et al.

PHYSIOLOGICAL REVIEWS (2017)

Review Oncology

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer

Luisa Iommarini et al.

FRONTIERS IN ONCOLOGY (2017)

Review Biochemistry & Molecular Biology

Dynamic chromatin regulation at Notch target genes

Benedetto Daniele Giaimo et al.

TRANSCRIPTION-AUSTIN (2017)

Review Oncology

HIF-1 at the crossroads of hypoxia, inflammation, and cancer

Kuppusamy Balamurugan

INTERNATIONAL JOURNAL OF CANCER (2016)

Review Biochemistry & Molecular Biology

The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways

Tilman Borggrefe et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Article Biochemistry & Molecular Biology

Regulation of HIF-1 alpha stability by lysine methylation

Sung Hee Baek et al.

BMB REPORTS (2016)

Review Biochemistry & Molecular Biology

EMT: 2016

M. Angela Nieto et al.

Review Cell Biology

Notch signalling in context

Sarah J. Bray

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Review Pharmacology & Pharmacy

Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer

Caroline Wigerup et al.

PHARMACOLOGY & THERAPEUTICS (2016)

Article Oncology

Targeting hypoxic response for cancer therapy

Elisa Paolicchi et al.

ONCOTARGET (2016)

Review Oncology

Hypoxia-Inducible Factors: Master Regulators of Cancer Progression

Luana Schito et al.

TRENDS IN CANCER (2016)

Review Oncology

The biology and function of fibroblasts in cancer

Raghu Kalluri

NATURE REVIEWS CANCER (2016)

Article Biochemistry & Molecular Biology

Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation

Lenka Skalska et al.

EMBO JOURNAL (2015)

Article Biochemistry & Molecular Biology

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness andmetastasis

Chris D. Madsen et al.

EMBO REPORTS (2015)

Article Medicine, Research & Experimental

F-box protein FBXW7 inhibits-cancer metastasis in a non-cell-autonomous manner

Kanae Yumimoto et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Medicine, Research & Experimental

Estrogen regulates Hippo signaling via GPER in breast cancer

Xin Zhou et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Cell Biology

Role of the Tumor Microenvironment in Breast Cancer

Savas D. Soysal et al.

PATHOBIOLOGY (2015)

Article Multidisciplinary Sciences

Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer

Jun Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision

Marcelo Boareto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Cell Biology

Ligand-Independent Mechanisms of Notch Activity

William Hunt Palmer et al.

TRENDS IN CELL BIOLOGY (2015)

Review Pharmacology & Pharmacy

Hypoxia-inducible factors in cancer stem cells and inflammation

Gong Peng et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2015)

Article Oncology

Interleukin-6 and pro inflammatory status in the breast tumor microenvironment

Alessandro Sanguinetti et al.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2015)

Editorial Material Oncology

The PHD2 oxygen sensor paves the way to metastasis

Anna Kuchnio et al.

ONCOTARGET (2015)

Article Oncology

Copper activates HIF-1α/GPER/VEGF signalling in cancer cells

Damiano Cosimo Rigiracciolo et al.

ONCOTARGET (2015)

Review Pharmacology & Pharmacy

HIF-1α pathway: role, regulation and intervention for cancer therapy

Georgina N. Masoud et al.

ACTA PHARMACEUTICA SINICA B (2015)

Article Multidisciplinary Sciences

TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity

Marina Stantic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemistry & Molecular Biology

Overexpression of ERβ is sufficient to inhibit hypoxia-inducible factor-1 transactivation

Choa Park et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Article Oncology

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

Panagiotis Ntziachristos et al.

CANCER CELL (2014)

Article Oncology

GPER Mediates Activation of HIF1α/VEGF Signaling by Estrogens

Ernestina Marianna De Francesco et al.

CANCER RESEARCH (2014)

Article Biochemistry & Molecular Biology

GPER activates Notch signaling in breast cancer cells and cancer-associated fibroblasts (CAFs)

Marco Pupo et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

Review Oncology

Dll4-Notch signaling in regulation of tumor angiogenesis

Zhaoguo Liu et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2014)

Article Oncology

GPER functions as a tumor suppressor in triple-negative breast cancer cells

Christine Weissenborn et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2014)

Article Multidisciplinary Sciences

Proline-Hydroxylated Hypoxia-Inducible Factor 1α (HIF-1α) Upregulation in Human Tumours

Cameron E. Snell et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

Hongfang Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

被撤回的出版物: Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells (Retracted article. See vol. 119, 2022)

Debangshu Samanta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Endocrinology & Metabolism

GPER function in breast cancer: an overview

Rosamaria Lappano et al.

FRONTIERS IN ENDOCRINOLOGY (2014)

Review Oncology

Stromal cells in tumor microenvironment and breast cancer

Yan Mao et al.

CANCER AND METASTASIS REVIEWS (2013)

Article Cell & Tissue Engineering

Hypoxia-Induced Secretion of TGF-β1 in Mesenchymal Stem Cell Promotes Breast Cancer Cell Progression

Shun-Pei Hung et al.

CELL TRANSPLANTATION (2013)

Article Oncology

Regulation of EMT by Notch Signaling Pathway in Tumor Progression

Yumei Li et al.

CURRENT CANCER DRUG TARGETS (2013)

Article Oncology

The Role of Snail in EMT and Tumorigenesis

Yifan Wang et al.

CURRENT CANCER DRUG TARGETS (2013)

Review Oncology

Role of hypoxia-inducible factors in breast cancer metastasis

Daniele M. Gilkes et al.

FUTURE ONCOLOGY (2013)

Review Biochemistry & Molecular Biology

Ubiquitinations in the Notch Signaling Pathway

Julien Moretti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Review Medicine, General & Internal

Tumour oxygenation: implications for breast cancer prognosis

H. Rundqvist et al.

JOURNAL OF INTERNAL MEDICINE (2013)

Article Biochemistry & Molecular Biology

17β-Estradiol promotes the invasion and migration of nuclear estrogen receptor-negative breast cancer cells through cross-talk between GPER1 and CXCR1

Qi-Feng Jiang et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Small molecules intercept Notch signaling and the early secretory pathway

Andreas Kraemer et al.

NATURE CHEMICAL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Breast tumor and stromal cell responses to TGF-β and hypoxia in matrix deposition

Colleen S. Curran et al.

MATRIX BIOLOGY (2013)

Article Oncology

Notch signaling induces EMT in OSCC cell lines in a hypoxic environment

Takayuki Ishida et al.

ONCOLOGY LETTERS (2013)

Article Cell & Tissue Engineering

Synergistic Effect of the γ-Secretase Inhibitor PF-03084014 and Docetaxel in Breast Cancer Models

Cathy C. Zhang et al.

STEM CELLS TRANSLATIONAL MEDICINE (2013)

Review Oncology

Regulatory networks defining EMT during cancer initiation and progression

Bram De Craene et al.

NATURE REVIEWS CANCER (2013)

Review Biochemistry & Molecular Biology

The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness

Bin Bao et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2012)

Review Biochemistry & Molecular Biology

Hypoxia-Inducible Factors in Physiology and Medicine

Gregg L. Semenza

Article Biochemistry & Molecular Biology

Notch signaling mediates TGF-β1-induced epithelial-mesenchymal transition through the induction of Snail

Yosuke Matsuno et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

Article Oncology

Regulation of CXCR4 gene expression in breast cancer cells under diverse stress conditions

Kleopatra Andreou et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2012)

Article Biochemistry & Molecular Biology

Hypoxia and estrogen are functionally equivalent in breast cancer-endothelial cell interdependence

Andrea L. George et al.

MOLECULAR CANCER (2012)

Review Genetics & Heredity

The Notch signalling system: recent insights into the complexity of a conserved pathway

K. G. Guruharsha et al.

NATURE REVIEWS GENETICS (2012)

Article Multidisciplinary Sciences

Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch

James M. Haughian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Cell Biology

Endocytic routes to Notch activation

Martin Baron

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Hypoxia-inducible factor 1 alpha represses the transcription of the estrogen receptor alpha gene in human breast cancer cells

Kwanghee Ryu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Review Developmental Biology

Notch signaling: simplicity in design, versatility in function

Emma R. Andersson et al.

DEVELOPMENT (2011)

Review Developmental Biology

Coordinating cell behaviour during blood vessel formation

Ilse Geudens et al.

DEVELOPMENT (2011)

Review Oncology

Notch regulation of tumor angiogenesis

Esther Bridges et al.

FUTURE ONCOLOGY (2011)

Article Biochemistry & Molecular Biology

The G Protein-coupled Receptor 30 Is Up-regulated by Hypoxia-inducible Factor-1α (HIF-1α) in Breast Cancer Cells and Cardiomyocytes

Anna Grazia Recchia et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial-Mesenchymal Transition

Min-Zu Wu et al.

MOLECULAR CELL (2011)

Article Biochemistry & Molecular Biology

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

Dan R. Robinson et al.

NATURE MEDICINE (2011)

Article Oncology

E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells

Jan Theys et al.

RADIOTHERAPY AND ONCOLOGY (2011)

Article Multidisciplinary Sciences

Interaction Between Notch and Hif-α in Development and Survival of Drosophila Blood Cells

Tina Mukherjee et al.

SCIENCE (2011)

Article Biochemistry & Molecular Biology

TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer

Susanna Stinson et al.

SCIENCE SIGNALING (2011)

Review Oncology

Notch signalling in solid tumours: a little bit of everything but not all the time

Prathibha Ranganathan et al.

NATURE REVIEWS CANCER (2011)

Review Clinical Neurology

Numb - From flies to humans

Benedict Yan

BRAIN & DEVELOPMENT (2010)

Review Biochemistry & Molecular Biology

Immunity, Inflammation, and Cancer

Sergei I. Grivennikov et al.

Article Medicine, Research & Experimental

Oxidative stress promotes myofibroblast differentiation and tumour spreading

Aurore Toullec et al.

EMBO MOLECULAR MEDICINE (2010)

Review Oncology

The multiple functions of Numb

Alberto Gulino et al.

EXPERIMENTAL CELL RESEARCH (2010)

Article Cell Biology

Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors

Kohei Yamamizu et al.

JOURNAL OF CELL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

Amar J. Majmundar et al.

MOLECULAR CELL (2010)

Article Multidisciplinary Sciences

Therapeutic antibody targeting of individual Notch receptors

Yan Wu et al.

NATURE (2010)

Article Cell Biology

The Role of the Microenvironment in Mammary Gland Development and Cancer

Kornelia Polyak et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Article Biochemistry & Molecular Biology

The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation

Julien Moretti et al.

PLOS BIOLOGY (2010)

Review Biochemistry & Molecular Biology

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

Raphael Kopan et al.

Review Biochemistry & Molecular Biology

Epithelial-Mesenchymal Transitions in Development and Disease

Jean Paul Thiery et al.

Article Biochemistry & Molecular Biology

Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF

Deo Prakash Pandey et al.

EMBO JOURNAL (2009)

Article Oncology

GPR30 predicts poor survival for ovarian cancer

Harriet O. Smith et al.

GYNECOLOGIC ONCOLOGY (2009)

Article Multidisciplinary Sciences

Direct inhibition of the NOTCH transcription factor complex

Raymond E. Moellering et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Regulation of endocytosis via the oxygen-sensing pathway

Yi Wang et al.

NATURE MEDICINE (2009)

Article Biochemistry & Molecular Biology

Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3

Kang Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Cell Biology

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster

Thomas Vaccari et al.

JOURNAL OF CELL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Polycomb complex 2 is required for E-cadherin repression by the snail1 transcription factor

Nicolas Herranz et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Review Cell Biology

The role of oxygen availability in embryonic development and stem cell function

M. Celeste Simon et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Article Multidisciplinary Sciences

AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand

Patricia Chastagner et al.

PLOS ONE (2008)

Article Multidisciplinary Sciences

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

Cecilia Sahlgren et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Oncology

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

Mark W. Dewhirst et al.

NATURE REVIEWS CANCER (2008)

Article Biochemistry & Molecular Biology

Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1

Shinji Tagami et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Endocrinology & Metabolism

The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-α

Archana Dhasarathy et al.

MOLECULAR ENDOCRINOLOGY (2007)

Review Physiology

Estrogen receptors:: How do they signal and what are their targets

Nina Heldring et al.

PHYSIOLOGICAL REVIEWS (2007)

Article Obstetrics & Gynecology

GPR30: a novel indicator of poor survival for endometrial carcinoma

Harriet O. Smith et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2007)

Article Multidisciplinary Sciences

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

Irene Noguera-Troise et al.

NATURE (2006)

Article Biochemistry & Molecular Biology

Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis

Jennifer L. Childress et al.

CURRENT BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Cell-specific regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α stabilization and transactivation in a graded oxygen environment

Cameron P. Bracken et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Oncology

Aberrant activation of Notch signaling in human breast cancer

S Stylianou et al.

CANCER RESEARCH (2006)

Review Biochemistry & Molecular Biology

Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

K Hirota et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Cell Biology

Tumor suppressor properties of the ESCRT-II complex component vps25 in Drosophila

BJ Thompson et al.

DEVELOPMENTAL CELL (2005)

Article Cell Biology

Hypoxia requires Notch signaling to maintain the undifferentiated cell state

MV Gustafsson et al.

DEVELOPMENTAL CELL (2005)

Review Immunology

Cytokines and the regulation of hypoxia-inducible factor (HIF)-1α

JJ Haddad et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2005)

Review Oncology

Notch signaling in development and disease

EM Hansson et al.

SEMINARS IN CANCER BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins

MB Wilkin et al.

CURRENT BIOLOGY (2004)

Article Cell Biology

Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor

N Gupta-Rossi et al.

JOURNAL OF CELL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex

H Peinado et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Multidisciplinary Sciences

The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription

S Brunnberg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

MTA3, a Mi-2/NuRD complex subunit, an invasive growth pathway in breast

N Fujita et al.

Article Biochemistry & Molecular Biology

Sequence determinants in hypoxia-inducible factor-1α for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3

JH Huang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

HS Lu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Multidisciplinary Sciences

Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype

A Jögi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Oncology

Levels of hypoxia-inducible factor-1α during breast carcinogenesis

R Bos et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2001)