Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/ijms19061726
Keywords
central nervous system; food intake; gastrointestinal tract; gut-brain axis; gut hormone; neuropeptide; orexigenic; phoenixin-14; phoenixin-20
Funding
- German Research Foundation [STE 1765/3-2]
- Charite University Funding [UFF 89/441-176]
- German Research Foundation (DFG)
- Open Access Publication Fund of Charite-Universitatsmedizin Berlin
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Phoenixin is a recently discovered brain peptide initially thought to be restricted to reproductive functions. The subsequent identification of phoenixin's expression in peripheral tissues was accompanied by the description of several other actions of this hormone, such as effects on behavior, sensory perception, memory retention, the cardiovascular system as well as food intake, pointing towards a pleiotropic role of this peptide. The present review will discuss the present knowledge on phoenixin and the signaling involved as well as highlight gaps in knowledge to stimulate further research.
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